Monday, February 22, 2021

Blacks have 3X false reports on pulse oximetry readings

 Trade journal


https://medcitynews.com/2021/02/fda-issues-warning-on-pulse-oximeter-limitations-but-says-little-about-racial-disparities/?rf=1


NEJM Letter


https://www.nejm.org/doi/full/10.1056/NEJMc2029240


"...Thus, in two large cohorts, Black patients had nearly three times the frequency of occult hypoxemia that was not detected by pulse oximetry as White patients. Given the widespread use of pulse oximetry for medical decision making, these findings have some major implications, especially during the current coronavirus disease 2019 (Covid-19) pandemic. Our results suggest that reliance on pulse oximetry to triage patients and adjust supplemental oxygen levels may place Black patients at increased risk for hypoxemia. It is important to note that not all Black patients who had a pulse oximetry value of 92 to 96% had occult hypoxemia. However, the variation in risk according to race necessitates the integration of pulse oximetry with other clinical and patient-reported data.

In device applications, the Food and Drug Administration requires reporting of demographic subgroups to mitigate risk. However, our findings highlight an ongoing need to understand and correct racial bias in pulse oximetry and other forms of medical technology."


Thursday, February 18, 2021

Dr Charnot Katsikas (U Chicago), PubMed

 https://medlabs.uchicago.edu/about/our-pathologists/profile/angella-charnot-katsikas/


Angella Charnot-Katsikas, MDMicrobiology and Infectious Disease

Assistant Professor and Assistant Director of the Clinical Microbiology and Immunology Laboratories Angella Charnot-Katiskas, MD, has an interest in medical microbiology and virology, specifically in bacterial resistance to antibiotics. She earned an undergraduate degree in biology from the University of Chicago and a medical degree from Rush Medical College. Charnot-Katiskas completed both a clinical pathology residency and a medical microbiology fellowship at UChicago. She also is medical director of the Laboratory at the University of Chicago Cancer Center at Silver Cross. She is a member of the Antimicrobial Stewardship Committee at UChicago as well as a member of the CRE Detect and Protect task force for the state of Illinois.

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https://pubmed.ncbi.nlm.nih.gov/?term=charnot-katsikas&sort=date&size=100


 
From Etest to Vitek 2: Impact of Enterococcal Linezolid Susceptibility Testing Methodology on Time to Active Therapy.
Nguyen CT, Bethel C, Pettit NN, Charnot-Katsikas A.Antimicrob Agents Chemother. 2020 Aug 20;64(9):e00302-20. doi: 10.1128/AAC.00302-20. Print 2020 Aug 20.PMID: 32540982
 
Clinical outcomes of IDH2-mutated advanced-phase Ph-negative myeloproliferative neoplasms treated with enasidenib.
Patel AA, Cahill K, Charnot-Katsikas A, Liu H, Gurbuxani S, Thirman M, Kosuri S, Artz AS, Larson RA, Stock W, Segal J, Odenike O.Br J Haematol. 2020 Jul;190(1):e48-e51. doi: 10.1111/bjh.16709. Epub 2020 May 1.PMID: 32358888 No abstract available.
 
Draft Genome Sequences of Two Acinetobacter baumannii Isolates from a Fatal Case of Necrotizing Fasciitis.
Arivett BA, Charnot-Katsikas A, Bethel C, Fiester SE, Actis LA.Microbiol Resour Announc. 2020 Mar 26;9(13):e00047-20. doi: 10.1128/MRA.00047-20.PMID: 32217671 Free PMC article.
 
Antimicrobial Stewardship Review of Automated Candidemia Alerts Using the Epic Stewardship Module Improves Bundle-of-Care Adherence.
Pettit NN, Han Z, Nguyen CT, Choksi A, Charnot-Katsikas A, Beavis KG, Tesic V, Pisano J.Open Forum Infect Dis. 2019 Oct 11;6(10):ofz412. doi: 10.1093/ofid/ofz412. eCollection 2019 Oct.PMID: 31660370 Free PMC article.
 
Comparison of 3 Nucleic Acid Amplification Tests and a Rapid Antigen Test with Culture for the Detection of Group A Streptococci from Throat Swabs.
Parker KG, Gandra S, Matushek S, Beavis KG, Tesic V, Charnot-Katsikas A.J Appl Lab Med. 2019 Sep;4(2):164-169. doi: 10.1373/jalm.2018.028696. Epub 2019 Jun 25.PMID: 31639661 Free article.
 
Mice Fed an Obesogenic Western Diet, Administered Antibiotics, and Subjected to a Sterile Surgical Procedure Develop Lethal Septicemia with Multidrug-Resistant Pathobionts.
Hyoju SK, Zaborin A, Keskey R, Sharma A, Arnold W, van den Berg F, Kim SM, Gottel N, Bethel C, Charnot-Katsikas A, Jianxin P, Adriaansens C, Papazian E, Gilbert JA, Zaborina O, Alverdy JC.mBio. 2019 Jul 30;10(4):e00903-19. doi: 10.1128/mBio.00903-19.PMID: 31363025 Free PMC article.
 
A Multi-Centered Case-Case-Control Study of Factors Associated With Klebsiella pneumoniae Carbapenemase-Producing Enterobacteriaceae Infections in Children and Young Adults.
Logan LK, Nguyen DC, Scaggs Huang FA, Qureshi NK, Charnot-Katsikas A, Bartlett AH, Zheng X, Hujer AM, Domitrovic TN, Marshall SH, Bonomo RA, Weinstein RA.Pediatr Infect Dis J. 2019 May;38(5):490-495. doi: 10.1097/INF.0000000000002176.PMID: 30169484 Free PMC article.
 
Improved rates of antimicrobial stewardship interventions following implementation of the Epic antimicrobial stewardship module.
Pettit NN, Han Z, Choksi AR, Charnot-Katsikas A, Beavis KG, Tesic V, Bhagat P, Nguyen CT, Bartlett AH, Pisano J.Infect Control Hosp Epidemiol. 2018 Aug;39(8):980-982. doi: 10.1017/ice.2018.130. Epub 2018 Jun 28.PMID: 29950188
 
Prevalence of a Cefazolin Inoculum Effect Associated with blaZ Gene Types among Methicillin-Susceptible Staphylococcus aureus Isolates from Four Major Medical Centers in Chicago.
Wang SK, Gilchrist A, Loukitcheva A, Plotkin BJ, Sigar IM, Gross AE, O'Donnell JN, Pettit N, Buros A, O'Driscoll T, Rhodes NJ, Bethel C, Segreti J, Charnot-Katsikas A, Singh K, Scheetz MH.Antimicrob Agents Chemother. 2018 Jul 27;62(8):e00382-18. doi: 10.1128/AAC.00382-18. Print 2018 Aug.PMID: 29891607 Free PMC article.
 
Multicenter Evaluation of the Modified Carbapenem Inactivation Method and the Carba NP for Detection of Carbapenemase-Producing Pseudomonas aeruginosa and Acinetobacter baumannii.
Simner PJ, Johnson JK, Brasso WB, Anderson K, Lonsway DR, Pierce VM, Bobenchik AM, Lockett ZC, Charnot-Katsikas A, Westblade LF, Yoo BB, Jenkins SG, Limbago BM, Das S, Roe-Carpenter DE.J Clin Microbiol. 2017 Dec 26;56(1):e01369-17. doi: 10.1128/JCM.01369-17. Print 2018 Jan.PMID: 29118172 Free PMC article.
 
Use of the Accelerate Pheno System for Identification and Antimicrobial Susceptibility Testing of Pathogens in Positive Blood Cultures and Impact on Time to Results and Workflow.
Charnot-Katsikas A, Tesic V, Love N, Hill B, Bethel C, Boonlayangoor S, Beavis KG.J Clin Microbiol. 2017 Dec 26;56(1):e01166-17. doi: 10.1128/JCM.01166-17. Print 2018 Jan.PMID: 29118168 Free PMC article.
 
HPV vaccine acceptability in high-risk Greek men.
Hoefer L, Tsikis S, Bethimoutis G, Nicolaidou E, Paparizos V, Antoniou C, Kanelleas A, Chardalias L, Stavropoulos GE, Schneider J, Charnot-Katsikas A.Hum Vaccin Immunother. 2018 Jan 2;14(1):134-139. doi: 10.1080/21645515.2017.1379640. Epub 2017 Oct 24.PMID: 28937851 Free PMC article.
 
The performance of Luminex ARIES® Flu A/B & RSV and Cepheid Xpert® Flu/RSV XC for the detection of influenza A, influenza B, and respiratory syncytial virus in prospective patient samples.
McMullen P, Boonlayangoor S, Charnot-Katsikas A, Beavis KG, Tesic V.J Clin Virol. 2017 Oct;95:84-85. doi: 10.1016/j.jcv.2017.08.018. Epub 2017 Sep 5.PMID: 28892765
 
Risk factors, prevalence, and site concordance of human papillomavirus in high-risk Greek men.
Tsikis S, Hoefer L, Bethimoutis G, Nicolaidou E, Paparizos V, Antoniou C, Chardalias L, Stavropoulos GE, Sharma S, Long BC, Mujacic I, Kadri S, Segal JP, Furtado LV, Schneider J, Charnot-Katsikas A.Eur J Cancer Prev. 2018 Sep;27(5):514-520. doi: 10.1097/CEJ.0000000000000366.PMID: 28394804 Free PMC article.
 
Modified Carbapenem Inactivation Method for Phenotypic Detection of Carbapenemase Production among Enterobacteriaceae.
Pierce VM, Simner PJ, Lonsway DR, Roe-Carpenter DE, Johnson JK, Brasso WB, Bobenchik AM, Lockett ZC, Charnot-Katsikas A, Ferraro MJ, Thomson RB Jr, Jenkins SG, Limbago BM, Das S.J Clin Microbiol. 2017 Aug;55(8):2321-2333. doi: 10.1128/JCM.00193-17. Epub 2017 Apr 5.PMID: 28381609 Free PMC article.
 
Comparison of Cepheid Xpert Flu/RSV XC and BioFire FilmArray for Detection of Influenza A, Influenza B, and Respiratory Syncytial Virus.
Wahrenbrock MG, Matushek S, Boonlayangoor S, Tesic V, Beavis KG, Charnot-Katsikas A.J Clin Microbiol. 2016 Jul;54(7):1902-1903. doi: 10.1128/JCM.00084-16. Epub 2016 Apr 20.PMID: 27098956 Free PMC article.
 
Fulminant hepatic failure attributed to infection with human herpesvirus 6 (HHV-6) in an immunocompetent woman: A case report and review of the literature.
Charnot-Katsikas A, Baewer D, Cook L, David MZ.J Clin Virol. 2016 Feb;75:27-32. doi: 10.1016/j.jcv.2015.12.002. Epub 2015 Dec 14.PMID: 26745830
 
Human papillomavirus infection by anatomical site among Greek men and women: a systematic review.
Tsikis S, Hoefer L, Charnot-Katsikas A, Schneider JA.Eur J Cancer Prev. 2016 Nov;25(6):558-71. doi: 10.1097/CEJ.0000000000000207.PMID: 26628088 Free PMC article. Review.
 
BioFire FilmArray Respiratory Panel for Detection of Enterovirus D68.
Shibib DR, Matushek SM, Beavis KG, Gawel SH, Charnot-Katsikas A.J Clin Microbiol. 2016 Feb;54(2):457-9. doi: 10.1128/JCM.02339-15. Epub 2015 Nov 25.PMID: 26607982 Free PMC article.
 
Comparison of turnaround time and time to oseltamivir discontinuation between two respiratory viral panel testing methodologies.
Pettit NN, Matushek S, Charnot-Katsikas A, Tesic V, Boonlayangoor S, Brielmaier B, Pisano J.J Med Microbiol. 2015 Mar;64(Pt 3):312-313. doi: 10.1099/jmm.0.000007. Epub 2015 Jan 13.PMID: 25587073 Free PMC article. No abstract available.
 
Staphylococcus aureus infection induces protein A-mediated immune evasion in humans.
Pauli NT, Kim HK, Falugi F, Huang M, Dulac J, Henry Dunand C, Zheng NY, Kaur K, Andrews SF, Huang Y, DeDent A, Frank KM, Charnot-Katsikas A, Schneewind O, Wilson PC.J Exp Med. 2014 Nov 17;211(12):2331-9. doi: 10.1084/jem.20141404. Epub 2014 Oct 27.PMID: 25348152 Free PMC article.
 
Prospective evaluation of the VITEK MS for the routine identification of bacteria and yeast in the clinical microbiology laboratory: assessment of accuracy of identification and turnaround time.
Charnot-Katsikas A, Tesic V, Boonlayangoor S, Bethel C, Frank KM.J Med Microbiol. 2014 Feb;63(Pt 2):235-241. doi: 10.1099/jmm.0.063636-0. Epub 2013 Nov 13.PMID: 24227878
 
Two cases of necrotizing fasciitis due to Acinetobacter baumannii.
Charnot-Katsikas A, Dorafshar AH, Aycock JK, David MZ, Weber SG, Frank KM.J Clin Microbiol. 2009 Jan;47(1):258-63. doi: 10.1128/JCM.01250-08. Epub 2008 Oct 15.PMID: 18923009 Free PMC article.
 
A CRASH course in procedural skills improves medical students' self-assessment of proficiency, confidence, and anxiety.
Stewart RA, Hauge LS, Stewart RD, Rosen RL, Charnot-Katsikas A, Prinz RA; Association for Surgical Education.Am J Surg. 2007 Jun;193(6):771-3. doi: 10.1016/j.amjsurg.2007.01.019.PMID: 17512294